Suppression of humoral immune response to hepatitis B surface antigen vaccine in BALB/C mice by 1-methyl-tryptophan co-administration
| Autor: | Eleftheriadis, T., Sparopoulou, T., Antoniadi, G., Liakopoulos, V., Ioannis Stefanidis, Galaktidou, G. |
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| Zdroj: | Scopus-Elsevier DARU : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences |
| Popis: | Background and the purpose of the study Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immune response. The purpose of this study was to determine the effect of the IDO inhibitor namely 1-methyl-DL-tryptophan (DL-1-MT) on antibody production after vaccination with hepatitis B surface (HBs) antigen. Methods Four groups of BALB/c mice were immunized with a HBs antigen vaccine. In the first group the vaccine had no DL-1-MT, whereas in the other three groups the vaccine contained 1 mg, 10 mg and 20 mg DL-1-MT. Blood samples were collected 5 weeks post-vaccination and anti-HBs antibodies in the serum were measured by ELISA. Results Compared to the three groups of mice that were immunized with the vaccines containing DL-1-MT, serum anti-HBs level was much higher in the mice that were immunized with the vaccine with out DL-1-MT. Conclusions Inhibition of IDO at the time of vaccination decreased humoral immune response to HBs antigen vaccine. The idea that IDO activity is simply immunosuppressive may need to be re-evaluated. |
| Databáze: | OpenAIRE |
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