Neurovirulent strains of herpes simplex virus type 1 are not necessarily competent for reactivatable latency

Autor: Y, Arao, A, Hatano, M, Yamada, F, Uno, S, Nii
Jazyk: angličtina
Rok vydání: 1991
Předmět:
Zdroj: Acta Medica Okayama. 45(2):117-121
ISSN: 0386-300X
Popis: Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.
Databáze: OpenAIRE