| Autor: |
M, Barenbrock, C, Spieker, S, Kerber, C, Vielhauer, A P, Hoeks, W, Zidek, K H, Rahn |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Journal of hypertension. 13(12 Pt 2) |
| ISSN: |
0263-6352 |
| Popis: |
To investigate the different effects of hypertension, hyperlipidaemia and atherosclerosis on the visco-elastic properties of large arteries.Vessel wall properties were determined in patients who had been subjected for the first time to coronary arteriography. Normotensive patients with no coronary disease (n = 15), one-vessel disease (n = 15) or two- or three-vessel disease (n = 15), 15 treated hypertensive patients (mean +/- SEM duration of hypertension 9.6 +/- 1.7 years) with no coronary disease and normocholesterolaemia and 15 healthy controls were matched for blood pressure, age and sex.Arterial distension of the common carotid artery was determined by using a multigate Doppler system. The blood pressure curve was recorded by finger plethysmography.The end-diastolic diameter was significantly higher in the hypertensives (P0.05) but not significantly different in the normotensives compared with the controls. Arterial distensibility was significantly lower in the hypertensive group [(13.3 +/- 0.8) x 10(-3)/kPa] than in the controls [(19.1 +/- 1.5) x 10(-3)/kP; P0.01), in the group with no coronary disease [(18.8 +/- 1.3) x 10(-3)/kPa; P0.01] and in those with one-vessel disease [(17.7 +/- 1.4) x 10(-3)/kPa; P0.05]. Arterial distensibility was not significantly lower in the hypertensives than in the group with two- or three-vessel disease [(15.0 +/- 1.0) x 10(-3)/kPa; NS). No significant correlation was found between cholesterol or lipoprotein(a) levels and arterial distensibility in the normotensive patients.Hypertension is the predominant factor affecting the visco-elastic properties of large arteries. Arterial compliance is significantly altered only in extensive atherosclerosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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