| Autor: |
Takashi, Nagasawa, Nobuaki, Tabata, Yoshiaki, Ito, Youichi, Aiba, Naoyuki, Nishizawa, David D, Kitts |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Molecular and cellular biochemistry. 252(1-2) |
| ISSN: |
0300-8177 |
| Popis: |
The present study focused on examining the efficacy of feeding a rutin-glucose derivative (G-rutin) to inhibit glycation reactions that can occur in muscle, kidney and plasma proteins of diabetic rats. Both thiobarbituric acid-reactive substance levels and protein carbonyl contents in muscle and kidney were significantly (p0.05) reduced in streptozotocin-induced diabetic rats fed G-rutin supplemented diet, compared to diabetic rats fed control diet. The N(epsilon)-fructoselysine content in muscle and kidney, a biomarker of early glycation reaction, was markedly (p0.05) increased by diabetes, but significantly (p0.05) reduced in diabetic rats fed G-rutin. Advanced glycation end-products (AGEs) in serum and kidney protein were measured by immunoblot using anti-AGE antibody, and were also reduced in diabetic rats fed dietary G-rutin. Feeding G-rutin also slightly inhibited aldose reductase activity in these animals. These results demonstrate for the first time that dietary G-rutin consumption can provide potential health benefits that are related to the inhibition of tissue glycation reactions common to diabetes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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