Phenotype and pathological significance of MCAM

Autor:	Smriti K, Raychaudhuri, Christine, Abria, Siba P, Raychaudhuri
Rok vydání:	2021
Předmět:	Inflammation Male T-Lymphocytes T-cells Arthritis Psoriatic Interleukin-17 Synovial Membrane CD146 Antigen Middle Aged Lymphocyte Subsets Arthritis Rheumatoid Phenotype CD146 Psoriatic arthritis Humans Cytokines Female Original Article Immunologic Memory MCAM
Zdroj:	Molecular Biology Reports
ISSN:	1573-4978
Popis:	Background CD146 (MCAM-melanoma cell adhesion molecule) is a cell surface adhesion molecule for Laminin 411. T cells expressing MCAM are mainly responsible for IL-17 production. IL-17 secreting T helper cells (Th17 cells) are critical for the pathogenesis of psoriatic arthritis (PsA). Here we hypothesized enrichment of CD146+IL-17+ memory T cells in PsA synovium and studied the association of CD146 expression and CD4+IL-17+ activated memory (CD11a+CD45RO+) T cells in synovial fluid and blood of PSA, rheumatoid arthritis (RA, a positive control) and osteoarthritis (OA) patients. Methods Hi-D FACS studies were done to identify IL-17 in CD4+CD146+CD45RO+ and CD8+CD146+CD45RO+ T cells. Results We observed that effector CD146+(MCAM+) T cells are enriched at the synovial inflammation site in PsA. Conclusion As CD146+ T cells are a key resource for IL-17 it is likely that the enrichment of these MCAM+ pathologic cells are critical for the disease process of PsA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ffb49058af94bfdeb2d9c0ed7e889aa4 https://pubmed.ncbi.nlm.nih.gov/34491483 Zobrazit plný text záznamu Full text from SpringerLink