| Autor: |
P T, Shea-Donohue, D, Nompleggi, A, Dubois |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
The Journal of pharmacology and experimental therapeutics. 219(2) |
| ISSN: |
0022-3565 |
| Popis: |
The effects of 15(S)-15 methyl prostaglandin (PG) F2 alpha (mePGF2 alpha) on gastric emptying and secretion were studied in five conscious chair-adapted rhesus monkeys. A dye dilution technique was used to determine simultaneously fractional emptying rate, hydrogen ion (H+) output, fluid output and H+ concentration of the gastric juice. A continuous s.c. infusion of either saline or mePGF2 alpha (1 or 2 micrograms/kg/min) was given during a 40-min basal period and after intragastric administration of an 80-ml water load. The PGF2 alpha analog significantly inhibited both basal and postload H+ output but did not alter fluid output. As a result, the basal and postload H+ concentration of the gastric juice was significantly decreased. In addition to its antisecretory effect, mePGF2 alpha significantly enhanced postload gastric fractional emptying. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
