[Association of Next Generation Sequencing Based Genotypic Profiling with MICM Characteristics in NPM1 Mutated Acute Myeloid Leukemia]

Autor:	Biao, Wang, Yun, Ling, Li, Dai, Wei-Ying, Gu, Xiu-Wen, Zhang, Shan-Shan, Xing, Hai-Qian, Li
Rok vydání:	2022
Předmět:	Leukemia Myeloid Acute fms-Like Tyrosine Kinase 3 Mutation High-Throughput Nucleotide Sequencing Humans Nuclear Proteins Prognosis Nucleophosmin
Zdroj:	Zhongguo shi yan xue ye xue za zhi. 30(1)
ISSN:	1009-2137
Popis:	To explain the clinicobiological heterogeneity of NPM1 mutated (NPM1Data of 238 NPM1In entire NPM1Co-existing FLT3-ITD in NPM1伴NPM1突变急性髓系白血病二代测序突变基因谱与MICM分型特征关联性分析.分析伴NPM1突变（NPM1收集苏州大学附属第三医院、南京医科大学附属常州第二人民医院和浙江医院收治的成人初诊AML患者，选取NGS资料完整的NPM1全部患者共检出240个NPM1突变事 件，其中10个（10/240，4.2%）为错义突变，均不累及W288或W290位点。这10例错义突变事件仅见于NPM1NPM1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ff4a8c190439b4722b9384272bc5b169 https://pubmed.ncbi.nlm.nih.gov/35123604 Zobrazit plný text záznamu