| Autor: |
H, Bender, P O, Zamora, B A, Rhodes, S, Guhlke, H J, Biersack |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 17(3B) |
| ISSN: |
0250-7005 |
| Popis: |
Somatostatin-receptors have been found to be overexpressed in a variety of neuro-endocrine and epithelial cancers. While the introduction of a long-acting somatostatin-analogue, octreotide, exerted mainly anti-cancer activity in neuro-endocrine tumors, no convincing results have been demonstrated in other cancers. RC-160, another somatostatin-analogue has been selected because of its high receptor affinity and its anti-cancer activity. 188Re is a generator produced radionuclide with favourable gamma and beta-emission, allowing diagnostic and therapeutic application. The results of in vivo biodistribution and therapeutic outcome following systemic, intralesional and intracavitary application in animal studies employing 188Re-RC-160 are summarized. Safety considerations, dosimetry estimates and applicable indications are outlined. The clinical impacts of this radiopharmaceutical in cancer management are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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