Autor: |
Aminetou Mint, Mohamed, Marie, Balsat, Catherine, Koering, Delphine, Maucort-Boulch, Nicolas, Boissel, Lea, Payen-Gay, Meyling, Cheok, Hussein, Mortada, Didier, Auboeuf, Christiane, Pinatel, Mohamed, El-Hamri, Isabelle, Tigaud, Sandrine, Hayette, Charles, Dumontet, Emeline, Cros, Pascale, Flandrin-Gresta, Olivier, Nibourel, Claude, Preudhomme, Xavier, Thomas, Franck-Emmanuel, Nicolini, Françoise, Solly, Denis, Guyotat, Lydia, Campos, Mauricette, Michallet, Antony, Ceraulo, Franck, Mortreux, Eric, Wattel |
Rok vydání: |
2016 |
Předmět: |
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Zdroj: |
Leukemia research. 56 |
ISSN: |
1873-5835 |
Popis: |
In AML, approximately one-third of expressed genes are abnormally spliced, including aberrant TET2 exon 2 expression. In a discovery cohort (n=99), TET2 exon 2 skipping (TET2E2S) was found positively associated with a significant reduction in the cumulative incidence of relapse (CIR). Age, cytogenetics, and TET2E2S were independent prognostic factors for disease-free survival (DFS), and favorable effects on outcomes predominated in cytogenetic normal (CN)-AML and younger patients. Using the same cutoff in a validation cohort of 86 CN-AML patients, TET2E2S |
Databáze: |
OpenAIRE |
Externí odkaz: |
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