Microphthalmia transcription factor: a specific marker for malignant melanoma

Autor:	J, Vachtenheim, J, Borovanský
Rok vydání:	2005
Předmět:	DNA-Binding Proteins Genetic Markers Microphthalmia-Associated Transcription Factor Skin Neoplasms Biomarkers Tumor Humans Immunohistochemistry Melanoma Transcription Factors
Zdroj:	Prague medical report. 105(3)
ISSN:	1214-6994
Popis:	The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::ff039e00541068e5acecf0a89f510b73 https://pubmed.ncbi.nlm.nih.gov/15782558 Zobrazit plný text záznamu