| Autor: |
G K, Shiu, A O, Sager, R B, Velagapudi, V K, Prasad, J P, Skelly |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Pharmaceutical research. 5(1) |
| ISSN: |
0724-8741 |
| Popis: |
The effect of differing fat contents of food on the bioavailability of theophylline following a 400-mg single dose of Theo-24 was studied in mini-swine. The pharmacokinetics of theophylline, following the intravenous administration of aminophylline equivalent to 5 mg/kg as a single dose, were also studied in the same animals. The terminal plasma half-life of theophylline following an i.v. dose was found to be approximately 24 hr. The volume of distribution, Vdext, and clearance following the i.v. dose were approximately 0.7 liter/kg and 0.023 liter/hr/kg, respectively. The terminal half-life of theophylline following the administration of theophylline capsules under fasting conditions was 21 hr. The average bioavailability under fasting conditions was approximately 80% compared to the i.v. dose. Food appeared to have decreased the rate of absorption but no significant effect on the extent of absorption. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink