| Autor: |
Xiufeng, Zhang, Emre, Aksoy, Thomas, Girke, Alexander S, Raikhel, Fedor V, Karginov |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 114(10) |
| ISSN: |
1091-6490 |
| Popis: |
A potential avenue to control the spread of mosquito disease vectors lies in reproductive events that follow a blood meal. A key component is the massive production of yolk proteins in the fat body tissue, governed by regulatory networks triggered by the available nutrients. MicroRNAs play a critical role in mosquito egg maturation, and deciphering their dynamics and targets is necessary to fully realize these regulatory processes. We carried out a tissue-specific and time-resolved characterization of microRNA expression in the Aedes aegypti fat body and integrated these results with transcriptome-wide determination of their mRNA targets, followed by validation. This extensive analysis lays the groundwork for a systemic understanding of the gene regulation that underpins reproductive events in the female mosquito. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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