Successful treatment with recombinant factor VIIa of therapy-resistant severe bleeding in a patient with acquired von Willebrand disease

Autor:	P W, Friederich, P C, Wever, E, Briët, C J, Doorenbos, M, Levi
Rok vydání:	2001
Předmět:	Male Paraproteinemias Hemorrhage Factor VIIa Recombinant Proteins Autoimmune Diseases Immunoglobulin kappa-Chains von Willebrand Diseases Antibody Specificity Immunoglobulin G von Willebrand Factor Humans Partial Thromboplastin Time Aged Paraproteins
Zdroj:	American journal of hematology. 66(4)
ISSN:	0361-8609
Popis:	We describe an elderly man who presented with life-threatening hematuria and gastrointestinal bleeding caused by acquired von Willebrand disease associated with monoclonal gammopathy of undetermined significance (MGUS). Standard therapy with desmopressin, von Willebrand factor-containing factor VIII concentrate, tranexamic acid, and immunoglobulin failed to achieve adequate hemostasis. However, treatment with recombinant activated factor VII (rFVIIa) arrested the bleeding completely. Since acquired von Willebrand disease can lead to life-threatening hemorrhage, clinicians should consider rFVIIa as an effective treatment option if standard therapy fails.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::feb39dddcc8b1c96cd80fa60a5d0b2fe https://pubmed.ncbi.nlm.nih.gov/11279642 Zobrazit plný text záznamu Plný text