| Autor: |
S, Nor Khairullah, N, Nor Fariza, A A Z, Roslin, T, Angelina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The Medical journal of Malaysia. 77(5) |
| ISSN: |
0300-5283 |
| Popis: |
Retinitis pigmentosa (RP) is a clinically and genetically heterogeneous group of hereditary disorders in which there is progressive loss of photoreceptors and pigment epithelial function culminating in complete vision loss. Unfortunately, given the disease's devastating effects, it is untreatable and there is often little that can be done to improve visual outcomes in these patients. The lack of curative intervention creates a challenge in the management of RP and its progression. As such, the main goal is to slow down the apoptosis and loss of photoreceptors in order to delay visual deterioration.We present two case illustrations of RP treated with WJ-MSC implanted in the deep subtenon space. Each patient underwent 4 sessions ranging from 1 to 3 months apart.At 3, 6, 9 and 12 months follow-up, the following were observed:(i) Both patients had no change in visual acuity and no further deterioration in vision or visual field.(ii) Optical coherence tomography showed a layer of hyperreflective material noted at the IO/OS junction area suggestive of a layer of new photoreceptors. The changes were noted in the macula and extramacular region for both patients.(iii) Both patients reported better discernment of colors and better vision at certain times during the day. (iv) No systemic or ocular adverse events were observed in the 12 month follow-up following the subtenon implantation of WJ-MSC.Subtenon implantation of WJ-MSC appears to be a feasible and safe option to consider in delaying the progression of retinal degeneration and improving the quality of life affected by visual deterioration in patients with RP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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