| Autor: |
Francesco, Deligia, Gabriele, Murineddu, Cecilia, Gotti, Giulio, Ragusa, Francesca, Fasoli, Miriam, Sciaccaluga, Simona, Plutino, Sergio, Fucile, Giovanni, Loriga, Battistina, Asproni, Gerard A, Pinna |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
European journal of medicinal chemistry. 152 |
| ISSN: |
1768-3254 |
| Popis: |
The cholinergic pathways in the central nervous system (CNS) of animals and humans are important for cognitive and behavioural functions. Until a few years ago, it was thought that the key molecules transducing the cholinergic message were the metabotropic muscarinic receptors, but it is now known that ionotropic neuronal nicotinic receptors (nAChRs) are also involved. Based on recent studies, we prepared a small library of novel 3-substituted-3,6-diazabicyclo [3.1.1]heptanes, whose binding activity and functionality have been assayed. Among the synthesized compounds, the 3-(anilino)pyridine series resulted in the most interesting compounds with α |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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