No correlation between serotonin and its metabolite 5-HIAA in the cerebrospinal fluid and [(11) C]AZ10419369 binding measured with PET in healthy volunteers

Autor:	Mikael, Tiger, Per, Svenningsson, Magdalena, Nord, Sandra, Jabre, Christer, Halldin, Johan, Lundberg
Rok vydání:	2014
Předmět:	Adult Male Serotonin Morpholines Brain Pilot Projects Hydroxyindoleacetic Acid Middle Aged Spinal Puncture Piperazines Young Adult Positron-Emission Tomography Humans Benzopyrans Radiopharmaceuticals
Zdroj:	Synapse (New York, N.Y.). 68(10)
ISSN:	1098-2396
Popis:	[(11) C]AZ10419369 is sensitive to pharmacologically enhanced endogenous serotonin levels. Twelve healthy volunteers underwent [(11) C]AZ10419369 PET and lumbar puncture. There were no correlations between [(11) C]AZ10419369 binding and concentrations of serotonin and its metabolite 5-HIAA in cerebrospinal fluid, suggesting that [(11) C]AZ10419369 brain binding does not reflect baseline serotonin levels in cerebrospinal fluid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fe53f2c983b505345ed0f40fbc904ae2 https://pubmed.ncbi.nlm.nih.gov/24988901 Zobrazit plný text záznamu Plný text