| Autor: |
Andrew V, Mossine, Sean S, Tanzey, Allen F, Brooks, Katarina J, Makaravage, Naoko, Ichiishi, Jason M, Miller, Bradford D, Henderson, Marc B, Skaddan, Melanie S, Sanford, Peter J H, Scott |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Org Biomol Chem |
| ISSN: |
1477-0539 |
| Popis: |
A one-pot two-step synthesis of 6-[(18)F]fluoro-L-DOPA ([(18)F]FDOPA) has been developed involving Cu-mediated radiofluorination of a pinacol boronate ester precursor. The method is fully automated, provides [(18)F]FDOPA in good activity yield (104 ± 16 mCi, 6 ± 1%), excellent radiochemical purity (>99%) and high molar activity (3799 ± 2087 Ci/mmol), n=3, and has been validated to produce the radiotracer for human use. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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