| Autor: |
Chantelli Iamblaudiot, Razafindrazoto, Lova Dany Ella, Razafindrabekoto, Domoina Harivonjy, Hasina Laingonirina, Raveloson, Raveloson, Anjaramalala Sitraka, Rasolonjatovo, Andry Lalaina Rinà, Rakotozafindrabe, Tovo Harimanana, Rabenjanahary, Soloniaina Hélio, Razafimahefa, Rado Manitrala, Ramanampamonjy |
| Rok vydání: |
2021 |
| Zdroj: |
JGH open : an open access journal of gastroenterology and hepatology. 6(3) |
| ISSN: |
2397-9070 |
| Popis: |
Beta blockers combined with endoscopic variceal band ligation (EVL) is the most effective means for the prevention of variceal rebleeding. No data are available on the efficacy of carvedilol in the secondary prophylaxis of variceal bleeding in hepatosplenic schistosomiasis. The aim of this study was to evaluate the efficacy and safety of carvedilol compared to propranolol as secondary prophylaxis of variceal bleeding in hepatosplenic schistosomiasis.This was a prospective, randomized study over a period of 14 months from February 2019 to March 2020. All patients with portal hypertension due to schistosomiasis with at least one episode of variceal bleeding were included and randomized to the propranolol and carvedilol groups. EVL protocol was continued in both groups.Sixty-one patients were eligible and randomized to propranolol (There was no significant difference in the efficacy between carvedilol and propranolol. Carvedilol may be an alternative to propranolol for secondary prophylaxis of variceal rebleeding in hepatosplenic schistosomiasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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