| Autor: |
N, Szentandrassy, B, Horvath, K, Vaczi, K, Kistamas, L, Masuda, J, Magyar, T, Banyasz, Z, Papp, P P, Nanasi |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 67(4) |
| ISSN: |
1899-1505 |
| Popis: |
Omecamtiv mecarbil (OM) is a myosin activator agent recently developed for treatment of heart failure. Although its action on extending systolic ejection time and increasing left ventricular ejection fraction is well documented, no data is available regarding its possible side-effects on cardiac ion channels. Therefore, the present study was designed to investigate the effects of OM on action potential morphology and the underlying ion currents in isolated canine ventricular myocytes using sharp microelectrodes, conventional patch clamp, and action potential voltage clamp techniques. OM displayed a concentration-dependent action on action potential configuration: 1 μM OM had no effect, while action potential duration and phase-1 repolarization were reduced and the plateau potential was depressed progressively at higher concentrations (10 - 100 μM; P0.05 compared to control). Accordingly, OM (10 μM) decreased the density of the transient outward K |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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