The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca

Autor:	María Dolores, Martin-de-Saavedra, Elisa, Navarro, Ana J, Moreno-Ortega, Mauricio P, Cunha, Izaskun, Buendia, Pablo, Hernansanz-Agustín, Rafael, León, María F, Cano-Abad, Antonio, Martínez-Ruiz, Ricardo, Martínez-Murillo, Michael R, Duchen, Manuela G, López
Rok vydání:	2017
Předmět:	Mice Transgenic Brain Ischemia Cell Line Mitochondria Oxygen Amyloid beta-Protein Precursor Mice Glucose Alzheimer Disease Astrocytes Mutation Presenilin-1 Animals Calcium
Zdroj:	Journal of neurochemistry. 145(2)
ISSN:	1471-4159
Popis:	Growing evidence suggests a close relationship between Alzheimer's Disease (AD) and cerebral hypoxia. Astrocytes play a key role in brain homeostasis and disease states, while some of the earliest changes in AD occur in astrocytes. We have therefore investigated whether mutations associated with AD increase astrocyte vulnerability to ischemia. Two astroglioma cell lines derived from APP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fe03d8da4c7ee0caab39470a1242d436 https://pubmed.ncbi.nlm.nih.gov/29315575 Zobrazit plný text záznamu Plný text