| Autor: |
G P, Mould, J A, Sutton, P, Matejtschuk, E W, Gascoigne, C H, Dash |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Vox sanguinis. 80(3) |
| ISSN: |
0042-9007 |
| Popis: |
The tolerability and pharmacokinetics of a solvent/detergent-treated intramuscular immunoglobulin were compared with those of the standard product.Single, 750-mg intramuscular (i.m.) injections were administered to a total of 36 healthy individuals: 23 in a double-blind trial and 13 in an open trial. Changes in specific serum hepatitis A and hepatitis B antibodies were monitored for a period of up to 3 months postinjection.No serious adverse reactions were reported, and the bioavailability of the solvent/detergent-treated preparation was equivalent to that of the standard i.m. immunoglobulin.There is no evidence that solvent/detergent treatment alters the pharmacokinetics or tolerance of human normal immunoglobulin, but it offers additional assurance against potential virus transmission. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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