| Autor: |
Víctor A, Sosa-Hernández, Sandra, Romero-Ramírez, Rodrigo, Cervantes-Díaz, Daniel A, Carrillo-Vázquez, Itze C, Navarro-Hernandez, Laura P, Whittall-García, Abdiel, Absalón-Aguilar, Ana S, Vargas-Castro, Raúl F, Reyes-Huerta, Guillermo, Juárez-Vega, David E, Meza-Sánchez, Vianney, Ortiz-Navarrete, Jiram, Torres-Ruiz, Nancy R, Mejía-Domínguez, Diana, Gómez-Martín, José L, Maravillas-Montero |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in immunology. 13 |
| ISSN: |
1664-3224 |
| Popis: |
Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), characterized by abnormal B cell activation and differentiation to memory or plasma effector cells. However, the role of these cells in the pathogenesis of LN is not fully understood, as well as the effect of induction therapy on B cell subsets, possibly associated with this manifestation, like aged-associated B cells (ABCs). Consequently, we analyzed the molecules defining the ABCs subpopulation (CD11c, T-bet, and CD21) through flow cytometry of blood samples from patients with lupus presenting or not LN, following up a small sub-cohort after six months of induction therapy. The frequency of ABCs resulted higher in LN patients compared to healthy subjects. Unexpectedly, we identified a robust reduction of a CD21 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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