Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward

Autor:	Peter E, Keipert
Rok vydání:	2017
Předmět:	Oxygen Hemoglobins Legislation Medical Blood Substitutes Animals Humans Wounds and Injuries Blood Transfusion
Zdroj:	Advances in experimental medicine and biology. 977
ISSN:	0065-2598
Popis:	Historically, hemoglobin-based oxygen carriers (HBOCs) were being developed as "blood substitutes," despite their transient circulatory half-life (~ 24 h) vs. transfused red blood cells (RBCs). More recently, HBOC commercial development focused on "oxygen therapeutic" indications to provide a temporary oxygenation bridge until medical or surgical interventions (including RBC transfusion, if required) can be initiated. This included the early trauma trials with HemAssist
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fdd7fe90298eb479f935f4f9519e6ec5 https://pubmed.ncbi.nlm.nih.gov/28685464 Zobrazit plný text záznamu