| Autor: |
Iskren, Kotzev, Irina, Ivanova, Maria, Atanassova, Antonia, Atanassova, Viara, Glinkova, Diana, Gancheva, Ivan, Shalev, Bogomila, Manevska, Ivan, Krasnaliev, Stela, Tomcheva |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Hepato-gastroenterology. 50(50) |
| ISSN: |
0172-6390 |
| Popis: |
Combination of interferon-alpha and ribavirin becomes the antiviral therapy of choice for chronic hepatitis C. The aim of this trial was to assess the efficacy of two combination treatment strategies: standard regimen Interferon-alpha 3 MU three times per week (group A) and initial high dose Interferon 6 MU daily for 2 weeks followed by intermittent administration 3 MU three times per week (group B), plus Ribavirin in naive and relapsed patients with chronic hepatitis C.Twenty-four patients (group A, 6; group B, 18) received medication for median 6 months (range, 5-12) and followed for 6 months. Primary end-point of therapy was a sustained virologic response. Statistical analysis was performed with a t test or non-parametric Mann-Whitney and chi-square test.At the end of the follow-up the overall sustained response rate was 42%: 6 of 18 (33.3%) patients with induction and 4 of 6 (66.6%) with standard regimen. Patients with sustained virologic response received higher interferon dose (423.7 +/- 102.2 MU) at extended duration of therapy (9.8 +/- 2.9 months) versus patients with non-sustained response (p0.05). The difference in sustained response rate in both treatment regimens was nonsignificant.High initial dose therapy does not enhance virologic response, compared to standard combination regimen. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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