| Autor: |
Yutong, Yao, Lanyun, Luo, Hua, Xue, Le, Luo, Haibo, Zou, Guan, Wang, Zhiming, An, Ming, Zhong, Xiaobing, Huang, Yifan, Zhu, Lingling, Wei, Maozhu, Yang, Tian, Zhang, Ping, Xie, Gang, Xu, Shaoping, Deng, Xiaolun, Huang |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 22(9) |
| ISSN: |
1007-3418 |
| Popis: |
To investigate whether transplantation of autologous peripheral blood CD34+ stem cells is a viable approach for treating patients with advanced cirrhosis,which is currently hindered by a shortage in liver donors.A total of 100 patients with advanced cirrhosis and who had failed to respond to conservative therapy were recruited for transplantation of autologous peripheral blood CD34+ stem cells.The success of transplantation was investigated 6-and 12-months later by measuring markers of liver biosynthesis function (coagulation,albumin level,indocyanine green clearance,Child-Pugh score) and assessing pathological changes (Knodell score) and morphologic changes in the liver tissue.Complications were also recorded during follow-up.The 1-year cumulative survival rate was 100%. Fifty-two patients with massive ascites showed gradual reduction and disappearance of the ascites.Four patients experienced upper gastrointestinal bleeding and three patients developed with hepatic encephalopathy (I-II degree) at 3 months post-transplantation.All patients showed significantly improved liver biosynthesis function,liver elasticity and Knodell score after transplantation (P less than 0.05).Autologous peripheral blood CD34+ stem cell transplantation is a safe and effective treatment for advanced cirrhosis,and has high cost-benefit since it improves liver function,liver histology,and quality of life. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
