| Autor: |
A W, Olusanya, A P, Arikawe, I C, Udenze, J A, Odoka, J O, Leigh |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 33(2) |
| ISSN: |
0794-859X |
| Popis: |
Cognitive impairment is a common adverse effect associated with carbamazepine use. One of the proposedmechanisms for cognitive impairment may be attributed to the pro-oxidant properties of carbamazepine. This studyinvestigated the effects of L-Arginine supplementation with carbamazepine on cognition in adult male non-epileptic rats.Adult male Sprague-Dawley rats with average weight 200g to 220g were divided into 4 groups; (1) Control group treatedwith distilled water, (2) L-Arginine group treated with L-Arginine (100mg/kg BW) in distilled water, (3) Carbamazepinegroup treated with carbamazepine (25mg/kg BW twice daily) in distilled water, and (4) Carbamazepine + L-Arginine grouptreated with Carbamazepine and L-Arginine as above for two weeks to assess the acute changes in cognition and oxidativestress markers. Following two weeks of treatment, cognition was assessed using the Y-maze, after which the rats werehumanely sacrificed with the hippocampus and frontal lobes isolated from the brain and subsequently homogenized forassessment of oxidative stress markers [(Catalase, superoxide dismutase (SOD), malondialdehyde (MDA), and reducedGlutathione (GSH)]. Arm entry and correct alternation were significantly higher (p0.05) in the L-Arginine and L-Arginine+ Carbamazepine groups compared to carbamazepine group. In the frontal lobe, L-Arginine significantly increased (p0.05)catalase and GSH levels compared to other groups while in the hippocampus, it significantly (p0.05) reduced MDA withno change in other parameters. Likewise, SOD and MDA levels were significantly lower (p0.05) in the L-Arginine +Carbamazepine group compared to other groups. Oral L-Arginine supplementation with carbamazepine improved cognitiveperformance on Y maze. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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