Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines

Autor:	M E, Wall, M C, Wani, F, Fullas, J B, Oswald, D M, Brown, T, Santisuk, V, Reutrakul, A T, McPhail, N R, Farnsworth, J M, Pezzuto
Rok vydání:	1994
Předmět:	Flavonoids Models Molecular Mice Molecular Conformation Tumor Cells Cultured Animals Humans Benzopyrans Drug Screening Assays Antitumor Antineoplastic Agents Phytogenic
Zdroj:	Journal of medicinal chemistry. 37(10)
ISSN:	0022-2623
Popis:	Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents from the flowers of Calycopteris floribunda Lamk. (Combretaceae). Compounds 1-3 showed a wide range of activity against a panel of solid tumor cell lines. Among the biflavonoids, calycopterone (1) is the major constituent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fd254a6e9527b96995f1ccbe9cd5d415 https://pubmed.ncbi.nlm.nih.gov/8182705 Zobrazit plný text záznamu