Examination of angiopoietin-like protein 4, neuropeptide Y, omentin-1 levels of obese and non-obese patients with polycystic ovary syndrome

Autor:	Meryem, Güneş, Neslihan, Bukan
Rok vydání:	2015
Předmět:	Adult Estradiol Dehydroepiandrosterone Sulfate Cholesterol HDL Androstenedione Cholesterol LDL Luteinizing Hormone GPI-Linked Proteins Case-Control Studies Lectins Sex Hormone-Binding Globulin Angiopoietin-Like Protein 4 Cytokines Humans Female Neuropeptide Y Testosterone Obesity Insulin Resistance Angiopoietins Triglycerides Polycystic Ovary Syndrome
Zdroj:	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 31(11)
ISSN:	1473-0766
Popis:	The pathogenesis of polycystic ovary syndrome (PCOS) and obesity is not clarified yet. But some parameters such as neuropeptide Y (NPY), angiopoietin-like protein (Angptl-4), omentin-1 are thought to be involved in this pathogenesis. In this study, we aimed to show possible effects of NPY, Angptl-4, omentin-1 throughout clinical parameters and hormones. Patients were divided into three groups. Group I; healthy volunteers, Group II; non-obese women with PCOS and group III; obese women with PCOS. Serum NPY, Angptl-4, free testosterone, total testosterone, luteinize hormone, sex hormone binding globulin, estradiol, dehydroepiandrosterone sulfate, androstenedione, triglycerides and low density lipoprotein cholesterol levels and HOMA-IR, Ferriman-Galwey scores were significantly higher in group II when compared with group I and similarly in group III when compared with group II (p 0.005). While comparing all PCOS patients (obese + non-obese) with healthy volunteers, omentin-1 and high density lipoprotein cholesterol levels were significantly low in PCOS group (p 0.005). As a result of this study, both in the obese and non-obese PCOS patients, there was a significant increase in levels of NPY and Angptl-4 and a significant decline in omentin-1 when compared to healthy subjects. In conclusion, insulin resistance in PCOS patients may be related to the differences of NPY, Angptl-4 and omentin-1 levels and the effects of these differences on metabolic pathways.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fcaf197bf209a3437aa6490968883347 https://pubmed.ncbi.nlm.nih.gov/26291814 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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