Cytologic, clinicopathologic, and molecular features of papillary thyroid carcinoma with prominent hobnail features: 10 case reports and systematic literature review
| Autor: | Lee, Young Sub, Kim, Yourha, Jeon, Sora, Bae, Ja Seong, Jung, So Lyung, Jung, Chan Kwon |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Proto-Oncogene Proteins B-raf Time Factors Biopsy DNA Mutational Analysis Disease-Free Survival Young Adult Biomarkers Tumor Humans Anaplastic Lymphoma Kinase Genetic Predisposition to Disease Thyroid Neoplasms Promoter Regions Genetic Telomerase Aged Neoplasm Staging Retrospective Studies Aged 80 and over Carcinoma Receptor Protein-Tyrosine Kinases Middle Aged Immunohistochemistry Survival Analysis Carcinoma Papillary Phenotype Treatment Outcome Thyroid Cancer Papillary Mutation Original Article Female |
| Popis: | The hobnail variant of papillary thyroid carcinoma (PTC) is a rare, aggressive variant in which > 30% of the tumor cells have hobnail features. The clinical behavior and pathologic characteristics of these tumors are still unclear due to the rarity of the entity. The present study aimed to investigate cytologic, clinical, pathological, and molecular features of the hobnail variant from our data and from the literature. We retrospectively retrieved 10 cases of hobnail variant from 2,904 consecutive PTC patients. Cytologic and histopathologic slides from those 10 patients were reviewed. We performed molecular analysis for BRAF, ALK, and TERT promoter mutations on paraffin blocks from surgical specimens, and further analyzed the clinicopathologic characteristics of all case reports published in the literature until now. Cytologically, all tumors were characterized by single cells with eccentric nuclei and tapering cytoplasm (comet-like cells), and syncytial or micropapillary clusters with apically placed nuclei resulting in a hobnail appearance in both conventional smears and liquid-based cytology. The BRAF V600E mutation was found in 8 cases (80%) whereas no cases had ALK fusion or TERT promoter mutations. In the literature review of 55 patients including our cases, most patients presented with advanced stage cancer, and disease-specific survival rates were 83%, 71%, and 54% at 5, 10, and 20 years after the initial surgery, respectively. Characteristic cytologic features can allow a preoperative diagnosis of the hobnail variant of PTC based on cytology specimens. Further studies should be performed to identify the molecular genetics of the variant. |
| Databáze: | OpenAIRE |
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