| Autor: |
A S, Monakhov, A V, Guljaev, A V, Aksenov, K P, Hanson |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Journal of experimentalclinical cancer research : CR. 21(3) |
| ISSN: |
0392-9078 |
| Popis: |
We revealed a family consisting of 25 persons which displayed high predisposition to malignant diseases of the gastrointestinal tract (GIT): rectal cancer (RC) was diagnosed in 2 patients, large intestine malignant polyposis (LIMP) in 1 patient, large intestine diffuse polyposis (LIDP) in 3 and uterus fibromyoma in 1 patient. Six members of the family were examined cytogenetically with the methaphase method on blood lymphocytes following G-banding of chromosomes. In 2 patients with LIDP was detected 8.7 and 16.7% of hyperaneuploid cells, respectively, and 20% of cells with double minute chromosomes (DMS) were detected in 1 LIDP patient. We suppose, that LIDP development in members of the family is related to the significant increase of proportion of hyperaneuploid and DMS-containing cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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