Effects of dexamethasone on cell-mediated immune responses in cattle sensitized to Mycobacterium bovis
| Autor: | M L, Doherty, H F, Bassett, P J, Quinn, W C, Davis, M L, Monaghan |
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| Rok vydání: | 1995 |
| Předmět: |
CD4-Positive T-Lymphocytes
Immunity Cellular Tuberculin Test Anti-Inflammatory Agents CD2 Antigens Receptors Antigen T-Cell gamma-delta Receptors Interleukin-2 CD8-Positive T-Lymphocytes Flow Cytometry Tuberculin Immunohistochemistry Mycobacterium bovis Dexamethasone Interferon-gamma Leukocyte Count Animals Cattle Female Immunization Tuberculosis Bovine Skin |
| Zdroj: | American journal of veterinary research. 56(10) |
| ISSN: | 0002-9645 |
| Popis: | Systemic administration of dexamethasone led to a significant reduction in the size of the tuberculin reaction in response to intradermal injection of bovine purified protein derivative in 18 cattle experimentally sensitized to Mycobacterium bovis (P0.01) and 8 cattle naturally infected with M bovis (P0.001). The reaction in 6 of the 7 M bovis infected cattle that received dexamethasone was classified as negative for the standard interpretation of the single intradermal comparative tuberculin test. Significantly fewer BoCD2+ (P0.05) and BoCD4+ T cells (P0.001) were present at the reaction site and in blood of dexamethasone-treated cattle, compared with untreated control cattle. Significantly fewer cells expressing the interleukin-2 receptor and WC1+ gamma delta T cells (P0.001), and a significantly greater number of cells expressing the ACT2 antigen (P0.05) were found at the reaction site in dexamethasone treated cattle than in controls. The number of BoCD8+ T cells at the reaction site and in blood was not significantly affected by administration of dexamethasone. In vitro production of interferon-gamma by lymphocytes incubated with bovine purified protein derivative also was significantly lower (P0.01) in the dexamethasone treated cattle. |
| Databáze: | OpenAIRE |
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