Peak Inspiratory Flows: Defining Repeatability Limits and a Predictive Equation for Different Inhalers
| Autor: | Chris N, Barnes, Donald A, Mahler, Jill A, Ohar, David A, Lombardi, Glenn D, Crater |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Chest. 158(4) |
| ISSN: | 1931-3543 0251-8139 |
| Popis: | Peak inspiratory flow (PIF) has been proposed as a measure to assess a patient's ability to use dry powder inhalers (DPIs). However, robust quality criteria to determine a repeatability limit for measuring PIF are lacking.What are the repeatability limits for measuring PIF? What is the relationship between PIF measured using the In-Check DIAL device at Diskus (GlaxoSmithKline; PIFData from a randomized, controlled, phase 3 trial (study 0149; see Clinical Trial Registration data) were used to define repeatability limits for PIF. In addition, a model to characterize the relationship between PIF measured with the In-Check DIAL device at PIFIn study 0128, the mean values (SD) for PIF at zero resistance and PIFThis analysis demonstrated that the two highest values of PIF using the In-Check DIAL device among three inspiratory efforts, met the repeatability limit. Altogether, these data provide guidance for measuring PIF against the simulated resistance of a specific DPI in clinical practice and research studies.ClinicalTrials.gov; Nos.: NCT02518139 (study 0128) and NCT03095456 (study 0149); URL: www.clinicaltrials.gov. |
| Databáze: | OpenAIRE |
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