| Autor: |
Aristides D, Tagalakis, Vignesh, Jayarajan, Ruhina, Maeshima, Kin H, Ho, Farhatullah, Syed, Lin-Ping, Wu, Ahmad M, Aldossary, Mustafa M, Munye, Talisa, Mistry, Olumide Kayode, Ogunbiyi, Arturo, Sala, Joseph F, Standing, Seyed M, Moghimi, Andrew W, Stoker, Stephen L, Hart |
| Rok vydání: |
2021 |
| Zdroj: |
Advanced functional materials. 31(37) |
| ISSN: |
1616-301X |
| Popis: |
The authors aim to develop siRNA therapeutics for cancer that can be administered systemically to target tumors and retard their growth. The efficacy of systemic delivery of siRNA to tumors with nanoparticles based on lipids or polymers is often compromised by their rapid clearance from the circulation by the liver. Here, multifunctional cationic and anionic siRNA nanoparticle formulations are described, termed receptor-targeted nanocomplexes (RTNs), that comprise peptides for siRNA packaging into nanoparticles and receptor-mediated cell uptake, together with lipids that confer nanoparticles with stealth properties to enhance stability in the circulation, and fusogenic properties to enhance endosomal release within the cell. Intravenous administration of RTNs in mice leads to predominant accumulation in xenograft tumors, with very little detected in the liver, lung, or spleen. Although non-targeted RTNs also enter the tumor, cell uptake appears to be RGD peptide-dependent indicating integrin-mediated uptake. RTNs with siRNA against |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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