| Autor: |
E D, Murphey, J F, Fessler, G D, Bottoms, H, Latshaw, M, Johnson, B, Mueller, W, Clark, W, Macias |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
American journal of veterinary research. 58(4) |
| ISSN: |
0002-9645 |
| Popis: |
To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock.16 clinically normal pigs.Endotoxin was infused, IV, into anesthetized pigs for a total of 50 minutes. Thirty minutes after termination of the infusion period, extracorporeal circulation was initiated through a 50-kd diafilter, or past the filter without ultrafiltrate formation. Cardiac and respiratory variables were monitored for a period of 4 hours.Infusion of lipopolysaccharide resulted in a severe hypodynamic circulatory state, with significant decreases in mean arterial pressure and cardiac output concurrent with a significant increase in pulmonary arterial pressure. Hemofiltration was not associated with any correction of lipopolysaccharide-induced cardiopulmonary derangements.Continuous venovenous hemofiltration, as used in this acute experiment, did not improve cardiopulmonary dysfunction during endotoxic shock.Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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