| Autor: |
B, Shapiro, J C, Sisson, D M, Wieland, T J, Mangner, S M, Zempel, E, Mudgett, M D, Gross, J E, Carey, K R, Zasadny, W H, Beierwaltes |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Journal of nuclear biology and medicine (Turin, Italy : 1991). 35(4) |
| ISSN: |
0368-3249 |
| Popis: |
Twenty-eight patients with histologically proven metastatic or invasive, unresectable pheochromocytomas, which were shown to concentrate and retain tracer doses of [131I]metaiodobenzylguanidine (131I-MIBG), were treated with therapeutic quantities of this radiopharmaceutical. Between one and six doses ranging from 97 to 301 mCi (cumulative dose 111-916 mCi) were administered. Partial response in tumor size was achieved in 8/28 patients and partial biochemical responses in 12/28 patients. No pharmacological toxicity was observed. Mild radiation sickness (nausea, vomiting, anorexia) occurred in 21/28. Minor degrees of leukopenia and thrombocytopenia were observed in 3/28. There were three cases of hypothyroidism but no significant hepatic, renal, adrenocortical or autonomic nervous dysfunction. We conclude that therapeutic 131I-MIBG can achieve significant therapeutic responses in some cases of malignant pheochromocytoma without pharmacological toxicity and only mild radiotoxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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