| Autor: |
Jianping, Chen, Artemis L, Yan, Kelly Y C, Lam, Candy T W, Lam, Ning, Li, Ping, Yao, Aizhen, Xiong, Tina T X, Dong, Karl W K, Tsim |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Phytotherapy research : PTR. 28(11) |
| ISSN: |
1099-1573 |
| Popis: |
The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as a health supplement worldwide. To study the role of jujube in brain benefits, the expression of neurotrophic factors and anti-oxidant enzymes in the jujube-treated cultured astrocytes was determined. Application of a chemical standardized water extract of jujube in cultured astrocytes for 24 h stimulated the expressions of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a concentration-dependent manner. The pre-treatment with H89, a protein kinase A inhibitor, attenuated the jujube-induced expression of neurotrophic factors. In parallel, the treatment of jujube water extract induced the transcriptional expressions of the enzymes responsible for anti-oxidation, i.e.quinine oxidoreductase 1, glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase modifier subunit and glutathione S-transferase, in a concentration-dependent manner. These results proposed the benefits of jujube in regulating expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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