| Autor: |
L A, Malikova, I B, Fedotova, N M, Surina, I I, Poletaeva, K S, Raevskiĭ |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 73(7) |
| ISSN: |
0869-2092 |
| Popis: |
The novel antiepileptic drug levetiracetam (keppra, 80 mg/kg, i.p.) produces a pronounced anticonvulsant effect on all parameters of the audiogenic locomotion response in Wistar rats, leading to the prevention of acoustic seizures approximately in 50% animals. Keppra injection also led to a decrease in the intensity of single audiogenic convulsive episode, a twofold prolongation of the latency of motor reaction, and a change in the pattern of seizure reaction toward increasing number of rats with "one-wave" response. In contrast, a lack of sound resistant animals and the change from one- to two-wave audiogenic response were observed in Krushinsky-Molodkina strain rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
