Semipreparative scale enantioseparation of racemic amine and amino ester hydrogen perchlorate salts using a silica gel-bound optically active di-tert-butylpyridino-18-crown-6 ligand

Autor:	Z, Köntös, P, Huszthy, J S, Bradshaw, R M, Izatt
Rok vydání:	2001
Předmět:	Perchlorates Molecular Structure Ethers Cyclic Molecular Conformation Solvents Silica Gel Salts Stereoisomerism Ligands Silicon Dioxide Sodium Compounds
Zdroj:	Enantiomer. 5(6)
ISSN:	1024-2430
Popis:	We report herein results on the enantioseparation of selected racemic amine and amino ester hydrogen perchlorate salts using a silica gel-bound optically pure chiral di-tert-butylpyridino-18-crown-6 ligand (R,R)-1. The effect of solvent composition was studied using appropriate binary and ternary solvent mixtures as eluents. We found that acetonitrile/ methanol/ dichloromethane (MeCN/MeOH/CH2 Cl2 ) ternary solvent mixtures gave better enantioseparations for the racemic salts using chiral stationary phase (R,R)-1 than any of the binary ones. In the present paper we also describe the studies of chromatographic parameters such as loading, flow rate and eluent polarity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fb7efe935288cf70dd6e1465d2d0ef2b https://pubmed.ncbi.nlm.nih.gov/11342291 Zobrazit plný text záznamu