| Autor: |
S, Yamada, T N, Mayadas, F, Yuan, D D, Wagner, R O, Hynes, R J, Melder, R K, Jain |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Blood. 86(9) |
| ISSN: |
0006-4971 |
| Popis: |
P-selectin-mediated rolling is believed to be important in the recruitment of leukocytes to tissue after ischemia-reperfusion injury. The dorsal skin chamber was used to examine differences in the rolling and stable adhesion of circulating leukocytes in subcutaneous (SC) vessels of P-selectin-deficient and age-matched wild-type mice, both under basal conditions and after ischemia-reperfusion. Rolling in the postcapillary venules in SC tissue of P-selectin-deficient mice was significantly lower than that in wild-type mice under the basal conditions and post-ischemia-reperfusion (P.05), but was not eliminated by the deletion of the P-selectin gene. No significant difference between P-selectin-deficient and wild-type mice in shear rate or leukocyte-endothelial adhesion was observed up to 24 hours after ischemia-reperfusion. These results show that P-selectin-mediated rolling is not a prerequisite for ischemia-reperfusion-induced leukocyte-endothelial adhesion in the skin. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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