Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway
| Autor: | M, Annicchiarico-Petruzzelli, F, Bernassola, P E, Lovat, C P, Redfern, A D, Pearson, G, Melino |
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| Rok vydání: | 2001 |
| Předmět: |
Fas Ligand Protein
Ion Transport Membrane Glycoproteins N-Methylaspartate Transglutaminases Apoptosis Drug Synergism HIV Envelope Protein gp120 Calcium Channel Blockers Nitric Oxide Receptors N-Methyl-D-Aspartate Neoplasm Proteins Gene Expression Regulation Neoplastic Interferon-gamma Neuroblastoma GTP-Binding Proteins Tumor Cells Cultured Humans Calcium Protein Glutamine gamma Glutamyltransferase 2 fas Receptor Nitric Oxide Synthase Excitatory Amino Acid Antagonists |
| Zdroj: | Medical and pediatric oncology. 36(1) |
| ISSN: | 0098-1532 |
| Popis: | The CD95/CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferongamma (INFgamma)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line.Modulation of CD95/CD95L expression and triggering of an autocrine apoptotic mechanism by IFNgamma suggest a potential role for INFgamma as a therapeutic agent for NB.The evidence that retinoids induce apoptosis via tissue transglutaminase (tTG) and that N-methyl-D-aspartate (NMDA) and gp120 act through the nitric oxide synthase (NOS) activation pathway, indicates the existence of different molecular mechanisms of action, whose pharmacological exploitation might be used in an additive fashion. |
| Databáze: | OpenAIRE |
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