| Autor: |
T O, Murashko, I V, Smirnov, A A, Ivanov, P S, Postnikov, A O, Nemtsev, A A, Bondarev, V V, Udut, A N, Prisukhin, A N, Kornaukhov, T S, Sergeev |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 79(5) |
| ISSN: |
0869-2092 |
| Popis: |
Gastric ulceration properties (gastrointestinal toxicity) of the sodium salt of 4-(0-β-D-glucopyranosyloxy) benzoic acid, a new nonsteroidal anti-inflammatory drug (NSAID) intended for the treatment of chronic inflammatory diseases of the kidney and urinary tract, have been tested on laboratory animals. Acute NSAID-induced gastropathy was induced in rats by oral administration of indomethacin, nimesulide, diclofenac, acetylsalicylic acid and the new drug. Test animals were killed by instantaneous decapitation 4 h after treatment and their gastrointestinal tracts were studied by pathomorphological methods on micropreparations and histological sections of gastric mucosa. It was established that the new drug, in contrast to reference NSAIDS, did not exhibit gastropathic action on the gastric mucosa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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