APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42

Autor:	J A, Prince, H, Zetterberg, N, Andreasen, J, Marcusson, K, Blennow
Rok vydání:	2004
Předmět:	Aged 80 and over Male Amyloid beta-Peptides Genotype Apolipoprotein E4 Peptide Fragments Cohort Studies Apolipoproteins E Gene Frequency Alzheimer Disease Humans Female Genetic Predisposition to Disease Alleles Aged
Zdroj:	Neurology. 62(11)
ISSN:	1526-632X
Popis:	The epsilon4 allele of APOE is a risk factor for Alzheimer disease (AD). By analysis of a large cohort of AD patients (n = 563) and control subjects (n = 118), it is shown that the epsilon4 allele is strongly associated with reduced CSF levels of beta-amyloid (1-42) (Abeta42) in both AD (p10(-9)) and control (p = 0.0012) populations. As no associations of APOE variants with other indexes of AD severity were observed, this effect may reflect a fundamental involvement of ApoE in Abeta metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fb399bd6a5d1a59162ba6d575f4edae1 https://pubmed.ncbi.nlm.nih.gov/15184629 Zobrazit plný text záznamu