The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease
| Autor: | Aimee, French, David, Balfe, James M, Mirocha, Jeremy A, Falk, Zab, Mosenifar |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Databases Factual Vital Capacity Kaplan-Meier Estimate Severity of Illness Index Pulmonary Disease Chronic Obstructive Sex Factors Predictive Value of Tests Risk Factors Forced Expiratory Volume Humans Lung Aged Proportional Hazards Models Retrospective Studies Original Research pulmonary function testing Chi-Square Distribution Total Lung Capacity Age Factors respiratory system Middle Aged mortality respiratory tract diseases Phenotype emphysema Pulmonary Emphysema Multivariate Analysis Pulmonary Diffusing Capacity Female Inspiratory Capacity |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| Popis: | Background Forced expiratory volume in 1 second (FEV1) grades severity of COPD and predicts survival. We hypothesize that the inspiratory capacity/total lung capacity (IC/TLC) ratio, a sensitive measure of static lung hyperinflation, may have a significant association with survival in an emphysematous phenotype of COPD. Objectives To access the association between IC/TLC and survival in an emphysematous phenotype of COPD. Methods We performed a retrospective analysis of a large pulmonary function (PF) database with 39,050 entries, from April 1978 to October 2009. Emphysematous COPD was defined as reduced FEV1/forced vital capacity (FVC), increased TLC, and reduced diffusing capacity of the lungs for carbon monoxide (DLCO; beyond 95% confidence intervals [CIs]). We evaluated the association between survival in emphysematous COPD patients and the IC/TLC ratio evaluated both as dichotomous (≤25% vs >25%) and continuous predictors. Five hundred and ninety-six patients had reported death dates. Results Univariate analysis revealed that IC/TLC ≤25% was a significant predictor of death (hazard ratio [HR]: 2.39, P |
| Databáze: | OpenAIRE |
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