Pharmacokinetics and metabolism of oral midazolam in preterm infants

Autor:	S N, de Wildt, G L, Kearns, W C J, Hop, D J, Murry, S M, Abdel-Rahman, J N, van den Anker
Rok vydání:	2002
Předmět:	Cytochrome P-450 Enzyme System Short Reports Midazolam Inactivation Metabolic Infant Newborn Administration Oral Cytochrome P-450 CYP3A Humans Hypnotics and Sedatives Oxidoreductases N-Demethylating Aryl Hydrocarbon Hydroxylases Infant Premature Half-Life
Zdroj:	British journal of clinical pharmacology. 53(4)
ISSN:	0306-5251
Popis:	To characterize the pharmacokinetics and metabolism of oral midazolam in 15 preterm infants.After an oral dose (0.1 mg kg(-1)), blood was drawn up to 24 h after administration. Midazolam and 1-OH-midazolam concentrations were determined with GC-MS. In 8 out of these 15 patients the pharmacokinetics of intravenous midazolam was also studied.Apparent oral clearance, apparent volume of distribution, plasma half-life and 1-OH-Midazolam/Midazolam AUC ratio were [median (range)]: 2.7 [0.67-15.5] ml kg(-1) min(-1), 1.4 [0.3-12.1] l kg(-1), 7.6 [1.2-15.1], h and 0.03 [0.01-0.96], respectively. Absolute bioavailability was 0.49 [0.12-1.0].Midazolam oral clearance is markedly decreased in preterm infants as compared with older children, probably because of immature CYP3A4 activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fae13ed46a18a08d539f2800b3ebfeb6 https://pubmed.ncbi.nlm.nih.gov/11966671 Zobrazit plný text záznamu Plný text