| Autor: |
I, Zebrowska-Lupina, T, Pietrasiewicz, G, Ossowska, T, Lupina, B, Klenk-Majewska |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 48(2) |
| ISSN: |
0867-5910 |
| Popis: |
Evidence exists that the 4-10 or 4-9 fragments of adrenocorticotropic hormone (ACTH) produce some behavioral effects in animals and in humans. The present study was designed to investigate whether ACTH 4-9 interferes with the effects of antidepressants: fluoxetine (FLU), fluvoxamine (FOX), selegiline (SEL) or dopamine agonists: piribedil (PRB) or quinpirol (QPR) in forced swimming test and in open field in rats. ACTH 4-9 was given in a single dose (25, 50 or 100 micrograms/kg) or for 7 days (50 micrograms/kg/day), alone or together with antidepressants or dopamine agonists. It was shown that ACTH 4-9 alone did not influence the behavior of rats. However, when given in a single dose, ACTH 4-9 potentiated the antiimmobility effect of all antidepressants and dopamine agonists. ACTH 4-9 given for 7 days, facilitated only the effect of selegiline. The results suggest a functional interaction of ACTH 4-9 with serotonergic and dopaminergic brain mechanisms of drugs action. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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