Composition of Gut Microbiota of Children and Adolescents With Perinatal Human Immunodeficiency Virus Infection Taking Antiretroviral Therapy in Zimbabwe
| Autor: | Flygel, Trym T, Sovershaeva, Evgeniya, Claassen-Weitz, Shantelle, Hjerde, Erik, Mwaikono, Kilaza S, Odland, Jon Ø, Ferrand, Rashida A, Mchugh, Grace, Gutteberg, Tore J, Nicol, Mark P, Cavanagh, Jorunn P, Flægstad, Trond |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Zimbabwe gut microbiota Adolescent Sequence Analysis RNA antiretroviral therapy HIV HIV Infections Viral Load HIV infection digestive system CD4 Lymphocyte Count Gastrointestinal Microbiome Major Articles and Brief Reports Cross-Sectional Studies children Anti-Retroviral Agents RNA Ribosomal 16S Africa Dysbiosis Humans Female Microbiome Child |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Human immunodeficiency virus (HIV) infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4+ T cells in the gut. Antiretroviral therapy (ART) restores CD4+ counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV-infected children. We investigated composition of gut microbiota in HIV-infected and -uninfected children and assessed associations between gut microbiota and patient characteristics. Methods In a cross-sectional study, rectal swabs were collected from 177 HIV-infected and 103 HIV-uninfected controls. Gut microbial composition was explored using 16S ribosomal ribonucleic acid sequencing. Results Human immunodeficiency virus-infected children had significantly lower alpha-diversity and higher beta-diversity compared to HIV-uninfected. No association was observed between microbiome diversity and CD4+ T-cell count, HIV viral load, or HIV-associated chronic lung disease. We found enriched levels of Corynebacterium (P < .01), Finegoldia (P < .01), and Anaerococcus (P < .01) in HIV-infected participants and enrichment of Enterobacteriaceae (P = .02) in participants with low CD4+ counts ( HIV-infected African children and adolescents have altered gut microbiota compared to HIV uninfected. ART was significantly associated with a higher alpha diversity, and prolonged ART may restore richness of the microbiota closer to that of HIV-uninfected children. |
| Databáze: | OpenAIRE |
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