Maternal-fetal transmission of SIV in macaques: disseminated adenovirus infection in an offspring with congenital SIV infection
| Autor: | H D, Ochs, W R, Morton, C C, Tsai, M E, Thouless, Q, Zhu, L D, Kuller, Y P, Wu, R E, Benveniste |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Adenoviridae Infections Simian Acquired Immunodeficiency Syndrome Brain Lymphocyte Activation Polymerase Chain Reaction Disease Models Animal Feces Liver Pregnancy Adenoviruses Simian Animals Female Simian Immunodeficiency Virus Lymph Nodes Macaca nemestrina Pregnancy Complications Infectious Antigens Viral Lung Pancreas |
| Zdroj: | Journal of medical primatology. 20(4) |
| ISSN: | 0047-2565 |
| Popis: | To develop a nonhuman primate model for maternal-fetal transmission of HIV infection, we have inoculated pregnant Macaca nemestrina with uncloned SIVMne. Three animals inoculated during the third trimester delivered healthy infants. One of the three infants, a male born 31 days after the mother was inoculated with SIV, became virus-positive but failed to produce SIV-specific antibody and died with overt simian immunodeficiency and disseminated adenovirus (SV20) infection at age six and one-half months. SIV and adenovirus antigen could be demonstrated by immunohistochemical methods in multiple organ systems. |
| Databáze: | OpenAIRE |
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