| Autor: |
Mutlay, Sayan, Prashant, Vempati, Brett, Miles, Marita, Teng, Eric, Genden, Elizabeth G, Demicco, Krzysztof, Misiukiewicz, Marshall, Posner, Vishal, Gupta, Richard L, Bakst |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Anticancer research. 36(8) |
| ISSN: |
1791-7530 |
| Popis: |
We compared the clinical outcomes and toxicity profile among a retrospective cohort of patients with primary major salivary gland carcinomas (SGCs) treated with surgery followed by adjuvant radiation therapy (S+RT) versus surgery and adjuvant chemoradiotherapy (S+CRT).Twenty patients (71%) underwent S+RT and eight (29%) S+CRT at our Institution between 2006 and 2015. Microscopic positive margins were present in 54% of the patients.The 3-year overall survival (OS) was 100% with S+RT and 87.5% with S+CRT (p=0.141) and locoregional control (LRC) was 95% with S+RT and 87.5% with S+CRT (p=0.383). There were no significant differences in the rate of acute (p=0.801) and late (p=0.714) toxicities.While we await randomized data, adjuvant CRT may be considered as a viable therapeutic option for patients at high-risk of local or regional recurrence, especially in those with a positive microscopic margin where further surgery may result in functional cranial neuropathies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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