| Autor: |
J, Pachecka, K, Kobylińska, B, Zagdańska, H, Zasłona, W, Bicz |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Acta poloniae pharmaceutica. 47(1-2) |
| ISSN: |
0001-6837 |
| Popis: |
Administration of diazepam or oxazepam caused a different response of the rat hepatic microsomal cytochrome P-450 dependent monooxygenase system. Both drugs produced significant decrease in the activity of NADH: cytochrome c oxidoreductase in rats exposed to 21 degrees C, but not to 28 degrees C and 35 degrees C, and did not change the activity of aniline hydroxylase, aminopyrine N-demethylase and 4-nitroanisole O-demethylase and cytochrome b5 level at any tested temperatures. Oxazepam, but not diazepam, caused a decrease in cytochrome P-450 content in rats exposed to 21 degrees C only. The results indicate that the high ambient temperature modifies the effect of tested benzodiazepines on the activity of some microsomal enzymes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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