Alteration of timing of secretion of vascular endothelial growth factors is responsible for progression of diabetic retinopathy

Autor:	L K, Mondal, K P, Baidya, G, Bhaduri, R, Bandyopadhyay, B, Bhattacharya
Rok vydání:	2008
Předmět:	Male Vascular Endothelial Growth Factor A Diabetic Retinopathy Time Factors Anaerobic Threshold India Middle Aged Oxidative Stress Cross-Sectional Studies Diabetes Mellitus Type 2 Malondialdehyde Disease Progression Humans Female Lactic Acid Glycolysis
Zdroj:	Journal of the Indian Medical Association. 106(8)
ISSN:	0019-5847
Popis:	Diabetic retinopathy is one of the most common complications in diabetes mellitus due to persistent hyperglycaemia. Various biochemical mechanisms have been suggested to cause this complication. The authors' present study which included 100 patients of type-2 diabetes mellitus with different stages of diabetic retinopathy and without retinopathy shows that initiation of diabetic retinopathy is associated with increased anaerobic glycolysis and accelerated oxidative stress. Progression of this complication is guided by increased secretion of vascular endothelial growth factors. It is our assumption that increased secretion of vascular endothelial growth factors in early part of this disease e.g. before occurrence of morphological abnormality may modify this complication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::fa93279b270fe3ae994e98ff4e114a89 https://pubmed.ncbi.nlm.nih.gov/18975510 Zobrazit plný text záznamu